9/27/2023 0 Comments Idarucizumab mechanism of action![]() ![]() The constituted solution must be mixed by repeated inversion of the diluent bag for 1 minute. Use 250 mg (2.5 mL) per 250 mL of diluent or 500 mg (5 mL) per 500 mL of diluent. The contents of each 2.5-mL vial should be diluted 100-fold by mixing with 250 mL of diluent. Preparation for Intravenous AdministrationĪrgatroban should be diluted in 0.9% Sodium Chloride Injection, 5% Dextrose Injection, or Lactated Ringer’s Injection to a final concentration of 1 mg/mL. Argatroban should not be mixed with other drugs prior to dilution in a suitable intravenous fluid. Evaluation of sera in 12 healthy subjects and 8 patients who received multiple doses of Argatroban did not reveal antibody formation to ArgatrobanĪrgatroban is indicated as an anticoagulant for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia.Īrgatroban is indicated as an anticoagulant in patients with or at risk for heparin-induced thrombocytopenia undergoing percutaneous coronary intervention (PCI).Īrgatroban is contraindicated in patients with overt major bleeding, or in patients hypersensitive to this product or any of its componentsĮach 2.5-mL vial contains 250 mg of Argatroban and, as supplied, is a concentrated drug (100 mg/mL), which must be diluted 100-fold prior to infusion. At therapeutic concentrations, Argatroban has little or no effect on related serine proteases (trypsin, factor Xa, plasmin, and kallikrein).Īrgatroban is capable of inhibiting the action of both free and clot-associated thrombin.Īrgatroban does not interact with heparin-induced antibodies. ![]() Argatroban exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation activation of coagulation factors V, VIII, and XIII activation of protein C and platelet aggregation.Īrgatroban is highly selective for thrombin with an inhibitory constant (Ki) of 0.04 µM. Argatroban does not require the co-factor antithrombin III for antithrombotic activity. ![]() Argatroban is a direct thrombin inhibitor that reversibly binds to the thrombin active site. ![]()
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